Evaluating CMR

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Dual-Energy X-Ray Absorptiometry (DEXA)


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Dual-energy x-ray absorptiometry (DEXA) was originally designed to measure bone mineral content, but it is now commonly used to assess total and regional fat and fat-free mass (Figure 1) (1, 2). DEXA assesses body composition based on the attenuation of x-rays emitted at two energy levels as they traverse the body (1, 2). DEXA provides less radiation exposure than CT and costs significantly less. A whole body DEXA scan requires 15 to 35 minutes depending on the scanner and is relatively easy to use in most populations as it requires very little participant effort (3). Once the scan is complete, it can be manually subdivided into truncal and appendicular regions. Measures of total and regional lean mass (coefficient of variation=1 to 7%) (4-6) and fat mass (coefficient of variation=1 to 7%) (5) are highly repeatable, but results may differ depending on the scanner model (e.g., Lunar, Holigic, etc.) (7), the software used (algorithms), and the individual’s sagittal diameter and hydration status (3). Nevertheless, DEXA measures of total or appendicular fat and lean mass closely match the fat and skeletal muscle values obtained by CT or MRI (4, 6, 8-10). Accordingly, DEXA is often used to assess total and appendicular percent fat mass with relatively good accuracy.


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1. Heymsfield S.B. LTG, Wang Z., Going S.B. Human Body Composition. Second Edition. Windsor ON. Human Kinetics. 2005.
2. Bray GA, Bouchard C and James WPT, eds. Handbook of obesity. New York: Marcel Dekker. 1998.
3. Brownbill RA and Ilich JZ. Measuring body composition in overweight individuals by dual energy x-ray absorptiometry. BMC Med Imaging 2005; 5: 1.
4. Kim J, Wang Z, Heymsfield SB, et al. Total-body skeletal muscle mass: estimation by a new dual-energy X-ray absorptiometry method. Am J Clin Nutr 2002; 76: 378-83.
5. Genton L, Hans D, Kyle UG, et al. Dual-energy X-ray absorptiometry and body composition: differences between devices and comparison with reference methods. Nutrition 2002; 18: 66-70.
6. Visser M, Fuerst T, Lang T, et al. Validity of fan-beam dual-energy X-ray absorptiometry for measuring fat-free mass and leg muscle mass. Health, Aging, and Body Composition Study--Dual-Energy X-ray Absorptiometry and Body Composition Working Group. J Appl Physiol 1999; 87: 1513-20.
7. Tylavsky F, Lohman T, Blunt BA, et al. QDR 4500A DXA overestimates fat-free mass compared with criterion methods. J Appl Physiol 2003; 94: 959-65.
8. Wang W, Wang Z, Faith MS, et al. Regional skeletal muscle measurement: evaluation of new dual-energy X-ray absorptiometry model. J Appl Physiol 1999; 87: 1163-71.
9. Salamone LM, Fuerst T, Visser M, et al. Measurement of fat mass using DEXA: a validation study in elderly adults. J Appl Physiol 2000; 89: 345-52.
10. Levine JA, Abboud L, Barry M, et al. Measuring leg muscle and fat mass in humans: comparison of CT and dual-energy X-ray absorptiometry. J Appl Physiol 2000; 88: 452-6.

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