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August 20, 2010Cardiovascular Disease, Inflammation, Insulin Resistance, News
Endoplasmic reticulum stress and atherosclerosis. Nat Med 2010;16:396-9

Hotamisligil GS. This paper reviews the recent advances concerning the role of endoplasmic reticulum (ER) stress in the pathogenesis of atherosclerosis and its complications. The ER is the site where all the proteins are formed. Under conditions...

August 20, 2010Diabetes, Inflammation, Insulin Resistance, News
Diacylglycerol-mediated insulin resistance. Nat Med 2010;16:400-2

Erion DM, Shulman GI. This review focuses on the effect of increases in intracellular diacylglycerol content on hepatic and skeletal muscle insulin resistance associated with obesity and type 2 diabetes. Overnutrition is the most common cause for...

August 19, 2010Adipose Tissue, Insulin Resistance, News, Obesity
Pioglitazone increases the proportion of small cells in human abdominal subcutaneous adipose tissue. Obesity 2010;18:926-31

McLaughlin TM, Liu T, Yee G, Abbasi F, Lamendola C, Reaven GM, Tsao P, Cushman SW, Sherman A. The objective of this study was to determine the effect of pioglitazone treatment on adipogenesis and insulin sensitivity in overweight/obese, nondiabetic...

August 13, 2010Cardiovascular Disease, Diabetes, Insulin Resistance, News
Pre-diabetes and the risk for cardiovascular disease: a systematic review of the evidence. J Am Coll Cardiol 2010;55:1310-7

Ford ES, Zhao G, Li C. The aim of this meta-analysis was to estimate the magnitude of the relative risk (RR) for cardiovascular disease (CVD) associated with impaired fasting glucose (IFG) and impaired glucose tolerance (IGT) from prospective...

August 12, 2010Adipokines, Insulin Resistance, News
Hypoadiponectinemia--cause or consequence of human "insulin resistance"? J Clin Endocrinol Metab 2010;95:1544-54

Cook JR, Semple RK. This review discusses the association between adiponectin and insulin resistance. It is now well recognized that adiponectin is an insulin-sensitizing adipokine. In fact, studies on adiponectin knockout mice models reported that...

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