International Chair on Cardiometabolic Risk

The Concept of CMR

Epidemiology

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CVD Risk and Type 2 Diabetes: Beyond Hyperglycemia

Metabolic syndrome

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Figure 2: Risk of coronary heart disease (CHD) in U.S. adults according to subgroups of metabolic syndrome (MS) components

It has been suggested that individuals with even 1 or 2 metabolic syndrome risk factors are at increased risk of mortality from coronary heart disease (CHD) and CVD. However, a large prospective study from the Second National Health and Nutrition Examination Survey (NHANES II) (20) lent further support to the notion that the metabolic syndrome more strongly predicted CHD, CVD, and total mortality than its individual components alone (Figure 2), confirming previous findings (21).

20. Malik S, Wong ND, Franklin SS, et al. Impact of the metabolic syndrome on mortality from coronary heart disease, cardiovascular disease, and all causes in United States adults. Circulation 2004; 110: 1245-50.

21. Isomaa B, Almgren P, Tuomi T, et al. Cardiovascular morbidity and mortality associated with the metabolic syndrome. Diabetes Care 2001; 24: 683-9.

Slide Library

Role of the Dysregulated Endocannabinoid System in Determining Cardiometabolic Risk by Vincenzo Di Marzo, PhD

Expert Opinions

What is the role of low HDL cholesterol in the elevated CHD risk of metabolic syndrome patients? By Philip J. Barter, MBBS, FRACP, PhD

Webcasts

Waist circumference: Getting it right! By Robert Ross, PhD

Key publications

Hypertrophy and hyperplasia of abdominal adipose tissues in women. Int J Obes (Lond) 2008;32:283-91

Image Base

Schematic representation of how smoking might add to several mechanisms linking obesity to cardiovascular disease