The Concept of CMR

Epidemiology

Hyperglycemia, Type 2 Diabetes and CVD Risk

Type 2 diabetes and CVD


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Patients with type 2 diabetes are at high risk of cardiovascular disease (CVD) (1). In fact, heart disease is the leading cause of death among patients with type 2 diabetes (2). In a seminal study, Haffner et al. (3) noted that the risk of cardiovascular complications in diabetic patients was similar to that of non-diabetic patients who had experienced myocardial infarction. The link between diabetes and CVD is complex and not fully understood.

People with diabetes have a higher CVD risk, possibly because they also tend to have traditional risk factors such as obesity, hypertension, and dyslipidemia (4). Other authors have suggested, however, that factors related to diabetes itself—such as hyperglycemia and hyperinsulinemia—could explain this elevated CVD risk (1).


Reference
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1. Kannel WB and McGee DL. Diabetes and cardiovascular disease. The Framingham study. JAMA 1979; 241: 2035-8.
2. Stamler J, Vaccaro O, Neaton JD, et al. Diabetes, other risk factors, and 12-yr cardiovascular mortality for men screened in the Multiple Risk Factor Intervention Trial. Diabetes Care 1993; 16: 434-44.
3. Haffner SM, Lehto S, Ronnemaa T, et al. Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction. N Engl J Med 1998; 339: 229-34.
4. Koskinen P, Manttari M, Manninen V, et al. Coronary heart disease incidence in NIDDM patients in the Helsinki Heart Study. Diabetes Care 1992; 15: 820-5.

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