The Concept of CMR

Epidemiology

Hyperglycemia, Type 2 Diabetes and CVD Risk

Metabolic Syndrome and CVD


Page: Go to Previous Page 5 of 6 Go to Next Page

The metabolic syndrome is very common in people with diabetes, and those with both diabetes and the metabolic syndrome have the highest rates of coronary heart disease (CHD) (Figure 1) (18). A recent prospective, 5 year community-based study of people with newly diagnosed type 2 diabetes found that the metabolic syndrome increased the risk of CVD events (19). Survival diminished progressively according to how many syndrome features patients displayed. These results confirmed UKPDS (14) findings that hyperglycemia per se may have a limited impact on CVD events in type 2 diabetes when the other features of the metabolic syndrome are taken into consideration (Figure 2).

Patients with type 2 diabetes are much more likely to experience cardiovascular complications. However, the link between diabetes and CVD is complex and not yet fully understood. Beyond the acknowledged impact of hyperglycemia, abdominal obesity-related risk factors may also play a role in the high incidence of cardiovascular events in diabetes.


Reference
Previous Reference
Next Reference
14. Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33). UK Prospective Diabetes Study (UKPDS) Group. Lancet 1998; 352: 837-53.
18. Alexander CM, Landsman PB, Teutsch SM, et al. NCEP-defined metabolic syndrome, diabetes, and prevalence of coronary heart disease among NHANES III participants age 50 years and older. Diabetes 2003; 52: 1210-4.
19. Guzder RN, Gatling W, Mullee MA, et al. Impact of metabolic syndrome criteria on cardiovascular disease risk in people with newly diagnosed type 2 diabetes. Diabetologia 2006; 49: 49-55.

Document Center


Role of the Dysregulated Endocannabinoid System in Determining Cardiometabolic Risk by Vincenzo Di Marzo, PhD

Role of the Dysregulated Endocannabinoid System in Determining Cardiometabolic Risk by Vincenzo Di Marzo, PhD

More

What is the role of low HDL cholesterol in the elevated CHD risk of metabolic syndrome patients? By Philip J. Barter, MBBS, FRACP, PhD

What is the role of low HDL cholesterol in the elevated CHD risk of metabolic syndrome patients? By Philip J. Barter, MBBS, FRACP, PhD

More

Waist circumference: Getting it right! By Robert Ross, PhD

Waist circumference: Getting it right! By Robert Ross, PhD

More

Hypertrophy and hyperplasia of abdominal adipose tissues in women. Int J Obes (Lond) 2008;32:283-91

Hypertrophy and hyperplasia of abdominal adipose tissues in women. Int J Obes (Lond) 2008;32:283-91

More

Schematic representation of how smoking might add to several mechanisms linking obesity to cardiovascular disease

Schematic representation of how smoking might add to several mechanisms linking obesity to cardiovascular disease

More