The Concept of CMR
Intra-abdominal Adipose Tissue: The Culprit?
Inflammation
- 1Key Points (1 page)
- 2Inflammation and obesity (2 pages)
- 3Inflammation and insulin resistance (1 page)
- 4Inflammation and dyslipidemia (1 page)
- 5Inflammation and CHD (1 page)
- 6References (1 page)
Key Points
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- Adipose tissue is more than an organ that mobilizes energy stored in the form of triglycerides. It is also an endocrine organ that secretes adipokines, which are involved in the atherogenic/diabetogenic metabolic risk profile of abdominal obesity.
- Obesity, especially intra-abdominal (visceral) obesity, is associated with chronic low-grade inflammation.
- This inflammation may lead to insulin resistance and other features of the metabolic syndrome associated with intra-abdominal obesity, such as dyslipidemia.
- The inflammatory component of CHD has been emphasized in recent years and may increase risk of acute coronary syndrome. However, hs-CRP may be a marker rather than a cause of metabolic disturbances that increase CVD risk.
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