The Concept of CMR
Intra-abdominal Adipose Tissue: The Culprit?
Pro-thrombotic State
- 1Key Points (1 page)
- 2Fat distribution and pro-thrombotic state (1 page)
- 3Hypofibrinolysis (1 page)
- 4Platelet hyperactivity (1 page)
- 5Hypercoagulability (1 page)
- 6Obesity and inflammation (1 page)
- 7Oxidative stress (1 page)
- 8Endothelial dysfunction (1 page)
- 9References (1 page)
Oxidative stress
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Oxidative stress is where the normal balance between the body’s pro-oxidant and anti-oxidant systems is disturbed in favour of oxidation (30). Oxidative stress from the production of reactive oxygen species (ROS) promotes endothelial dysfunction, platelet aggregation, and thrombus formation (31) (Figure). Many obesity-related metabolic abnormalities, such as hyperglycemia, dyslipidemia, and inflammation, all increase ROS production in the endothelium, which promotes oxidative stress (32).
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Role of the Dysregulated Endocannabinoid System in Determining Cardiometabolic Risk by Vincenzo Di Marzo, PhD
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What is the role of low HDL cholesterol in the elevated CHD risk of metabolic syndrome patients? By Philip J. Barter, MBBS, FRACP, PhD
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Hypertrophy and hyperplasia of abdominal adipose tissues in women. Int J Obes (Lond) 2008;32:283-91
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Schematic representation of how smoking might add to several mechanisms linking obesity to cardiovascular disease
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