The number of people suffering from type 2 diabetes is skyrocketing worldwide. This phenomenon has been closely linked to soaring obesity, which has reached epidemic proportions in populations around the world. But just why are we facing this “two-pronged assault” by overweight/obesity and type 2 diabetes? The answer is rather simple. The machines we use and the environments in which we live and work are designed to spare us from physical exertion. Unfortunately, this sedentary environment worsens the effects of the energy-dense, refined, “fast food” diet that more and more people are adopting. Taken together, our environment and our diet lead to a positive energy balance, weight gain, and obesity. As obesity reaches epidemic proportions, so too does type 2 diabetes. Unless we make significant changes to both our diet and way of life, obesity and type 2 diabetes will continue to exact a heavy toll on societies worldwide.

Which factors/markers do you think will emerge as key predictors of global CMR beyond the Framingham risk score?
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Tesaglitazar, a dual peroxisome proliferator-activated receptor alpha/gamma agonist, improves apolipoprotein levels in non-diabetic subjects with insulin resistance. Atherosclerosis 2008;197:355-62
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Evidence for a greater relative accumulation of intra-abdominal adipose tissue (AT) in Japanese than Caucasian Americans
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