Obesity and related comorbidities occur when energy intake exceeds energy expenditure over time.
In sedentary individuals, resting metabolic rate accounts for a large part of total energy expenditure.
Physical activity increases energy expenditure by increasing resting metabolic rate, enhancing sensitivity to specific hormones, and decreasing post-exercise energy intake.
Physical activity has the greatest impact on total daily energy expenditure. However, a high level of physical activity is required for this to occur.
Exercise benefits cardiovascular health and risk factors beyond what can be explained by increased energy expenditure.
Evaluation of the association between the first observation and the longitudinal change in C-reactive protein, and all-cause mortality. Heart 2008;94:457-62